Clinician-ordered advanced genetic screening, biannual blood testing, and access to clinical services for early detection of potential disease.ΔLearn about Important Information for Total health
- Identify disease risks with next-generation sequencing.
- Biannual blood testing with advanced cardiometabolic biomarkers.
- Meet with clinicians trained in genetics-informed care to receive a personalized health plan tailored to you.
- JUST ADDED Monitor how your body is aging physiologically and change the trajectory of your health with our Biological Age feature.
- Includes 23andMeplus PremiumTM
- Valid payment method required at kit registration.
Not available to residents of HI, NJ, NY, OK, RI and US territories. Not currently available to existing 23andMe customers. Sign up to be the first to know when it’s available.
‡Our genotyping product detects 250 health-related variants in our Carrier Status and Genetic Health Risk reports. The Exome Sequencing reports detect 50,000+ hereditary disease-causing variants.
23andMeplus Total Health members get the most advanced and comprehensive insights and recommendations we offer.
Interpretations of 100+ genes linked to 55+ conditions
Biannual results based on key blood biomarkers associated with aging.
Analysis of 55+ blood biomarkers
Virtual clinical consultation and unlimited messaging
190+ genotyping reports on your ancestry, health, traits and more.
Important test info
Exome Sequencing.Early detection and prevention powered by clinical-grade sequencing.
Exome sequencing is comprehensive genetic testing that analyzes a portion of your total DNA which contains the majority of genetic variants associated with disease risk. 23andMeplus Total Health offers clinician-ordered exome sequencing and clinical interpretations of 100+ high impact genes associated with 55+ health conditions that, if detected early, may have effective preventive measures and clinical interventions. You’ll get 6 reports, including:
Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.
Image Description: A sample result for Hereditary Cardiovascular Disease report; "No variants detected (of 44 genes tested) for inherited heart conditions."
Includes conditions that increase your risk for breast, ovarian, and colorectal cancer.
Image Description: A sample result for Hereditary Cancer report; "No variants detected (of 33 genes tested) for hereditary cancers."
Includes conditions like Parkinson's and Alzheimer's Disease.
Image Description: A sample result for Hereditary Neurological Disease report; "A variant was detected in the APOE gene." The e2 variant in the APOE gene is associated with a reduced risk for Alzheimer’s disease.
Hereditary Cardiovascular Disease
Includes conditions that increase your risk for arrhythmia, heart attacks, and aneurysms.
Total HealthYear
longevity and physiological aging.Monitor your Biological Age and change the trajectory of your health.
You know your calendar age, but do you know your biological age? Biological Age is our feature that analyzes key biomarkers, which reflect the condition of major body systems and organs.
Two Biological Age results are included each year so you can track and take steps to improve your biomarkers. Unlike your calendar age, your Biological Age can potentially slow down or even reverse with lifestyle changes, enhancing your longevity.
Biological Age
Biological Age is our feature that analyzes key biomarkers.
Blood Testing.Genetics provides insight into the future. Labs provide insight into the now.
Get comprehensive blood tests that assess 55+ biomarkers, including ones that go beyond your routine labs. Biannual testing allows you to track results and measure progress all within your 23andMe account. Blood testing is initiated by a clinician and offered at one of Quest Diagnostics’ convenient patient service centers. Biomarkers include:
Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).
Image Description: A sample result for Thyroid-stimulating hormone (TSH) report; "Your TSH levels are in the normal range." What is TSH? TSH (Thyroid-stimulating hormone) helps control the level of thyroid hormones in the blood.
Rarely tested, Lp(a) is the stickiest of the “bad” cholesterols and most likely to cause blockages in the arteries, increasing risk for cardiovascular disease.
Image Description: A sample result for Lipoprotein(a) (Lp(a)) report; "Your Lp(a) levels are in the optimal range." What is Lp(a)? High Lp(a) is a mostly inherited heart disease risk factor. A simple blood test can show whether your level is high.
In addition to other cholesterol testing, ApoB is being recognized as a key part of providing a more accurate and complete picture of a person’s overall risk for cardiovascular disease.
Image Description: A sample result for Apolipoprotein B (ApoB) report; "Your ApoB levels are in the moderate range." What is ApoB? Apolipoprotein B (ApoB) is the main protein in several types of “bad” cholesterol particles in the blood.
HbA1c can help in diagnosing and monitoring prediabetes and diabetes. Most people are unaware they have prediabetes due to lack of symptoms so testing is the only way to uncover it.
Image Description: A sample result for Hemoglobin A1c (HbA1c) report; "Your HbA1c levels are in the abnormal range." What is HbA1c? HbA1c shows average blood sugar level and can be helpful for understanding long-term trends in blood sugar.
Thyroid-stimulating hormone (TSH)
Thyroid disorders can have a big impact on your health, but are often undiagnosed. TSH is used to identify hypothyroidism (too little thyroid hormone) or hyperthyroidism (too much).
Clinical Consultation.Clinicians with unique knowledge and training in genetics-informed care.
These clinicians are committed to you on your preventive health journey. Together, you can discuss your genetic reports, blood test results, family history, lifestyle and more to understand your risks and build a preventive health plan that’s tailored to you - all within your 23andMe account.
A dedicated consultation to help you better understand your reports, generate risk assessments and provide next steps, with the ultimate goal of prevention.
Image Description: A sample secure message exchange between a patient and clinician
Have ongoing conversations with clinicians about your reports, your progress or questions about your health journey.
Image Description: A sample secure message exchange between a patient and clinician
Virtual Clinical Consultation
A dedicated consultation to help you better understand your reports, generate risk assessments and provide next steps, with the ultimate goal of prevention.
Check out what you’ll get in your Total Health membership.
- Hereditary Cancer ReportCoverage includes the following conditions:
- APC-associated polyposis (Gene: APC)
- ATM-associated cancers (Gene: ATM)
- Juvenile polyposis syndrome (Gene: BMPR1A, SMAD4)
- Hereditary breast and ovarian cancer (Gene: BRCA1, BRCA2)
- CHEK2-associated cancers (Gene: CHEK2)
- Hereditary prostate cancer (Gene: HOXB13)
- Hereditary paraganglioma-pheochromocytoma syndrome (Gene: MAX, SDHAF2, SDHB, SDHC, SDHD, TMEM127)
- Multiple endocrine neoplasia type 1 (Gene: MEN1)
- Lynch syndrome (Gene: MLH1, MSH2, MSH6, PMS2)
- MUTYH-associated polyposis (Gene: MUTYH)
- NF2-related schwannomatosis (Gene: NF2)
- Hereditary breast cancer (Gene: PALB2)
- Polymerase proofreading-associated polyposis (Gene: POLD1, POLE)
- PTEN hamartoma tumor syndrome (Gene: PTEN)
- Retinoblastoma (Gene: RB1)
- Familial medullary thyroid cancer (Gene: RET)
- Multiple endocrine neoplasia type 2a (Gene: RET)
- Multiple endocrine neoplasia type 2b (Gene: RET)
- Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome (Gene: SMAD4)
- Peutz-Jeghers syndrome (Gene: STK11)
- Li-Fraumeni syndrome (Gene: TP53)
- Tuberous sclerosis complex (Gene: TSC1, TSC2)
- Von Hippel-Lindau syndrome (Gene: VHL)
- Wilms tumor (Gene: WT1)
- Hereditary Cardiovascular Disease ReportCoverage includes the following conditions:
- Familial thoracic aortic aneurysm and dissection (Gene: ACTA2, MYH11)
- Familial hypertrophic cardiomyopathy (Gene: ACTC1, MYBPC3, MYH7, MYL2, MYL3, PRKAG2, TNNI3, TNNT2, TPM1)
- Familial hypercholesterolemia (Gene: APOB, LDLR, LDLRAP1, PCSK9)
- Type III hyperlipoproteinemia (Gene: APOE)
- Dilated cardiomyopathy (Gene: BAG3, DES, FLNC, LMNA, MYH7, RBM20, SCN5A, TNNC1, TNNT2, TTN)
- Myofibrillar myopathy (Gene: BAG3, DES, FLNC)
- Long QT syndrome (Gene: CALM1, CALM2, CALM3, KCNH2, KCNQ1, SCN5A, TRDN)
- Catecholaminergic polymorphic ventricular tachycardia (Gene: CALM1, CALM2, CALM3, CASQ2, RYR2, TRDN)
- Ehlers-Danlos syndrome, vascular type (Gene: COL3A1)
- Arrhythmogenic right ventricular cardiomyopathy (Gene: DSC2, DSG2, DSP, PKP2, TMEM43)
- Dilated cardiomyopathy with wooly hair, palmoplantar keratoderma, and tooth agenesis (Gene: DSP)
- Marfan syndrome (Gene: FBN1)
- Brugada syndrome (Gene: SCN5A)
- Loeys-Dietz syndrome (Gene: SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2)
- Hereditary Metabolic Disease ReportCoverage includes the following conditions:
- Biotinidase deficiency (Gene: BTD)
- G6PD deficiency (Gene: G6PD)
- Pompe disease (Gene: GAA)
- Fabry disease (Gene: GLA)
- Maturity-onset diabetes of the young (Gene: HNF1A)
- Ornithine carbamoyltransferase deficiency (Gene: OTC)
- Hereditary Kidney Disease ReportCoverage includes the following conditions:
- APOL1-related chronic kidney disease (Gene: APOL1)
- Autosomal dominant polycystic kidney disease (Gene: PKD1, PKD2)
- Hereditary Neurological Disease ReportCoverage includes the following conditions:
- Alzheimer's disease (Gene: APOE)
- Parkinson's disease (Gene: GBA, LRRK2)
- Other Hereditary Conditions
- Hereditary hemorrhagic telangiectasia (Gene: ACVRL1, ENG)
- Wilson's disease (Gene: ATP7B)
- Malignant hyperthermia (Gene: CACNA1S, RYR1)
- Ehlers-Danlos syndrome, classic type (Gene: COL5A1, COL5A2)
- Hereditary thrombophilia (Gene: F2, F5)
- Hereditary hemochromatosis (Gene: HFE)
- Leber congenital amaurosis (Gene: RPE65)
- Retinitis pigmentosa (Gene: RPE65)
- Alpha-1 antitrypsin deficiency (Gene: SERPINA1)
- Hereditary transthyretin-related amyloidosis (Gene: TTR)
- Comprehensive Metabolic Panel
- Blood Glucose
- Blood Urea Nitrogen (BUN)
- Creatinine
- Blood Urea Nitrogen/Creatinine ratio (BUN/Cr)
- Sodium
- Potassium
- Chloride
- Bicarbonate (Carbon dioxide)
- Calcium
- Total Protein
- Albumin
- Globulin
- Albumin/Globulin
- Bilirubin
- Alkaline phosphatase
- Aspartate aminotransferase (AST)
- Alanine aminotransferase (ALT)
- Estimate Glomerular filtration rate (eGFR)
- Complete Blood Count (CBC) Panel
- White Blood Cell Count (WBC)
- Red Blood Cell Count (RBC)
- Hemoglobin
- Hematocrit
- Erythrocyte mean corpuscular volume (MCV)
- Erythrocyte mean corpuscular hemoglobin (MCH)
- Erythrocyte mean corpuscular hemoglobin concentration (MCHC)
- Red Blood Cell distribution width (RDW)
- Platelet Count
- Neutrophil %
- Neutrophil Count
- Band Neutrophil %
- Band Neutrophil Count
- Metamyelocyte %
- Metamyelocyte Count
- Myelocyte %
- Myelocyte Count
- Promyelocyte %
- Promyelocyte Count
- Lymphocyte %
- Lymphocyte Count
- Variant Lymphocyte %
- Monocyte %
- Monocyte Count
- Eosinophil %
- Eosinophil Count
- Basophil %
- Basophil Count
- Blast %
- Blast Count
- Nucleated Red Blood Cell %
- Nucleated Red Blood Cell Count
- Mean platelet volume (MPV)
- Advanced Lipid Panel
- Triglycerides
- Total Cholesterol
- HDL (High-Density Lipoprotein)
- LDL (Low-Density Lipoprotein)
- Total Cholesterol / HDL Mass Ratio
- Non-HDL Cholesterol
- Apolipoprotein B (ApoB) (one time only)
- Lipoprotein (a) (Lp(a)) (one time only)
- Endocrine Blood Tests
- Thyroid-stimulating hormone (TSH) (one time only)
- Hemoglobin A1c (HbA1c)
- Ancestry Detail Reports (48 reports)
Population-specific reports with maps covering 3000+ regions, offering a granular view of your ancestry, plus immersive educational content.
Reports included:
Americas (Caribbean, Mexico & Central America, Indigenous American, South America);
East Asia (Chinese, Chinese Dai, Filipino & Austronesian, Indonesian, Thai, Khmer & Myanma, Japanese, Korean, Manchurian & Mongolian, Siberian, Vietnamese);
Europe (Ashkenazi Jewish, British & Irish, Eastern European, Finnish, French & German, Greek & Balkan, Italian, Sardinian, Scandinavian, Spanish & Portuguese);
Oceania (Melanesian);
Central & South Asia (Bengali & Northeast Indian, Central Asian, Gujarati Patidar, Malayali Subgroup, Northern Indian & Pakistani, Southern Indian & Sri Lankan, Southern Indian Subgroup);
Sub-Saharan Africa (African Hunter-Gatherer, Angolan & Congolese, Ethiopian & Eritrean, Ghanaian, Liberian & Sierra Leonean, Nigerian, Senegambian & Guinean, Somali, Southern East African, Sudanese);
Western Asia & North Africa (Anatolian, Coptic Egyptian, Cypriot, Egyptian, Iranian, Caucasian & Mesopotamian, Levantine, North African, Peninsular Arab) - Family Tree
- Maternal Haplogroup
- Paternal Haplogroup
- Neanderthal Ancestry
- Ability to Match Musical Pitch
- Asparagus Odor Detection
- Back Hair (available for men only)
- Bald Spot (available for men only)
- Bitter Taste
- Bunions
- Cheek Dimples
- Cilantro Taste Aversion
- Cleft Chin
- Dandruff
- Earlobe Type
- Early Hair Loss (available for men only)
- Earwax Type
- Eye Color
- Fear of Heights
- Fear of Public Speaking
- Finger Length Ratio
- Flat Feet
- Freckles
- Hair Photobleaching (hair lightening from the sun)
- Hair Texture
- Hair Thickness
- Ice Cream Flavor Preference
- Light or Dark Hair
- Misophonia (hatred of the sound of chewing)
- Mosquito Bite Frequency
- Motion Sickness
- Newborn Hair
- Photic Sneeze Reflex
- Red Hair
- Skin Pigmentation
- Stretch Marks
- Sweet vs. Salty
- Toe Length Ratio
- Unibrow
- Wake-Up Time
- Widow's Peak
- Hereditary Prostate Cancer (HOXB13-Related)A DNA variant that increases risk for prostate cancer1 variant in the HOXB13 gene; relevant for European (especially Northern European) descent
- Anxiety
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing anxiety that interferes with daily lifeBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Asthma
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a chronic lung condition characterized by shortness of breath, wheezing, and coughingBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Atrial Fibrillation
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a type of irregular heartbeatBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Attention-Deficit/Hyperactivity Disorder (ADHD)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of having ADHD, which can be associated with differences in attention, memory, and managing thoughts or behaviorsBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Bipolar Disorder
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of experiencing unusual shifts in mood, energy, activity, behavior, and sleep, beyond the normal ups and downs of lifeBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Breast Cancer (available for females only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing breast cancerBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Colorectal Cancer
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing cancer of the colon or rectumBased on a genetic model that includes customers' results for more than a thousand genetic markers; genetic result available for people with predominantly European and Hispanic/Latino ancestryThere is not enough data to create a genetic prediction that meets our scientific standards for people with other ancestries at this time. - Coronary Artery Disease
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a type of heart diseaseBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Depression
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing persistent low mood, loss of interest, and other symptoms that interfere with daily lifeBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Diverticulitis
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a condition that occurs when small pouches in the digestive tract become inflamedBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Eczema (Atopic Dermatitis)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a skin condition characterized by dry, discolored, and itchy skinBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Fibromyalgia
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a condition characterized by chronic pain and tenderness throughout the bodyBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Gallstones
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing solid, pebble-like masses that form in the gallbladderBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Gestational Diabetes (available for females only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a type of diabetes that occurs during pregnancyBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Glaucoma
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing an eye condition that can cause partial vision loss and blindnessBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Gout
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a condition where one or more joints suddenly becomes painful and swollenBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Hashimoto’s Disease
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing an autoimmune condition in which the immune system causes damage to the thyroid glandBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - HDL Cholesterol
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing low levels of HDL (“good”) cholesterolBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - High Blood Pressure
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing high blood pressureBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Insomnia
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a sleep disorder that causes chronic trouble with falling or staying asleepBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Irritable Bowel Syndrome
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a chronic condition that impacts the large intestineBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Kidney Stones
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for solid, pebble-like masses that form in the kidneysBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - LDL Cholesterol
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing high levels of LDL ("bad") cholesterolBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Lupus
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a chronic autoimmune condition that can affect many parts of the body, such as the joints, skin, lungs, kidneys, and heartBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Migraine
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of experiencing migraine headachesBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Nonalcoholic Fatty Liver Disease
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a condition where fat builds up in the liverBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Obstructive Sleep Apnea
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a condition where breathing stops and starts repeatedly during sleepBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Panic Attacks
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of experiencing episodes of intense fear that last a few minutes to an hourBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Polycystic Ovary Syndrome (PCOS) (available for females only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a hormone disorder that affects femalesBased on a genetic model that includes customers' results for more than a thousand genetic markers; variants found in many ethnicities - Preeclampsia (available for females only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing persistent high blood pressure during pregnancyBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Prostate Cancer (available for males only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing cancer of the prostate, a male reproductive organBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Psoriasis
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing an autoimmune condition that can cause itchy, discolored patches to form on the skinBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Restless Legs Syndrome
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a condition characterized by an uncontrollable urge to move one's legsBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Rosacea
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a chronic skin condition that often causes redness or visible blood vessels in the faceBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Severe Acne
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a skin condition characterized by many deep and painful types of pimples along with many whiteheads and blackheadsBased on a genetic model that includes customers' results for thousands of genetic markers; variants found in many ethnicities - Skin Cancer (Basal and Squamous Cell Carcinomas)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing the two most common types of skin cancerBased on a genetic model that includes customers’ results for thousands of genetic markers; genetic result available for people of European, Hispanic/Latino, Northern African/Central & Western Asian, and Sub-Saharan African/African American descentOnly about 3 in 1000 23andMe research participants of East/Southeast Asian or South Asian descent report having been diagnosed with basal or squamous cell skin cancers. This means there is not enough data to create a genetic prediction that meets our scientific standards for people of these ethnicities at this time. - Skin Cancer (Melanoma)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing a common type of skin cancerBased on a genetic model that includes customers’ results for more than a thousand genetic markers; genetic result available for people of European, Hispanic/Latino, and Northern African/Central & Western Asian descentOnly about 1 in 1000 23andMe research participants of East/Southeast Asian, South Asian, or Sub-Saharan African/African American descent report having been diagnosed with melanoma. This means there is not enough data to create a genetic prediction that meets our scientific standards for people of these ethnicities at this time. - Triglycerides
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood of developing high levels of triglycerides (a type of lipid)Based on a genetic model that includes customers' results for more than a thousand genetic markers; variants found in many ethnicities - Uterine Fibroids (available for females only)
(Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a common type of non-cancerous growth in the uterusBased on a genetic model that includes customers' results for more than a thousand genetic markers; variants found in many ethnicities
- Type 2 Diabetes (Powered by 23andMe Research)Reports and features that are “Powered by 23andMe Research” are developed by 23andMe scientists using data and insights gathered from thousands of customers who have consented to participate in our research.Genetic likelihood for a disorder of blood sugar regulation1,000+ variants in many genes; variants found in many ethnicities
- Age-Related Macular DegenerationGenetic risk for a form of adult-onset vision loss2 variants in the ARMS2 and CFH genes; relevant for European descent
- Alpha-1 Antitrypsin DeficiencyGenetic risk for lung and liver disease2 variants in the SERPINA1 gene; relevant for European descent
- BRCA1/BRCA2 (Selected Variants)Genetic risk based on a limited set of variants for breast, ovarian, prostate and pancreatic cancer44 variants in the BRCA1 and BRCA2 genes; most relevant for Ashkenazi Jewish descent; does not include the majority of BRCA1/2 variants found in people of other ethnicities
- Celiac DiseaseGenetic risk for gluten-related autoimmune disorder2 variants near the HLA-DQB1 and HLA-DQA1 genes; relevant for European decent
- Chronic Kidney Disease (APOL1-Related)Genetic risk for a form of chronic kidney disease2 variants in the APOL1 gene; relevant for African descent
- Familial HypercholesterolemiaGenetic risk for very high cholesterol, which can increase the risk for heart disease24 variants in the LDLR and APOB genes; relevant for European, Lebanese, Old Order Amish descent
- G6PD DeficiencyGenetic risk for a form of anemia2 variants in the G6PD gene; relevant for African, Southern European, Kurdish Jewish, Middle Eastern, Central Asian, South Asian descent
- Hereditary Amyloidosis (TTR-Related)Genetic risk for a form of nerve and heart damage3 variants in the TTR gene; relevant for African American, West African, Portuguese, Brazilian, Northern Swedish, Japanese, Irish, British descent
- Hereditary Hemochromatosis (HFE‑Related)Genetic risk for iron overload2 variants in the HFE gene; relevant for European descent
- Hereditary ThrombophiliaGenetic risk for harmful blood clots2 variants in the F2 and F5 genes; relevant for European descent
- Late-Onset Alzheimer's DiseaseGenetic risk for a form of dementia1 variant in the APOE gene; variant found and studied in many ethnicities
- MUTYH-Associated PolyposisGenetic risk for a specific colorectal cancer syndrome2 variants in the MUTYH gene; relevant for Northern European descent
- Parkinson's DiseaseGenetic risk for a form of movement impairment2 variants in the LRRK2 and GBA genes; relevant for European, Ashkenazi Jewish, North African Berber descent
- ARSACS1 variant in the SACS gene; relevant for French Canadian descent
- Agenesis of the Corpus Callosum with Peripheral Neuropathy1 variant in the SLC12A6 gene; relevant for French Canadian descent
- Autosomal Recessive Polycystic Kidney Disease3 variants in the PKHD1 gene
- Beta Thalassemia and Related Hemoglobinopathies10 variants in the HBB gene; relevant for Sardinian, Cypriot, Italian/Sicilian, Greek descent
- Bloom Syndrome1 variant in the BLM gene; relevant for Ashkenazi Jewish descent
- Canavan Disease3 variants in the ASPA gene; relevant for Ashkenazi Jewish descent
- Congenital Disorder of Glycosylation Type 1a (PMM2-CDG)2 variants in the PMM2 gene; relevant for Ashkenazi Jewish, Danish descent
- Cystic Fibrosis29 variants in the CFTR gene; relevant for Ashkenazi Jewish, European, Hispanic/Latino descent
- D-Bifunctional Protein Deficiency2 variants in the HSD17B4 gene
- Dihydrolipoamide Dehydrogenase Deficiency1 variant in the DLD gene; relevant for Ashkenazi Jewish descent
- Familial Dysautonomia1 variant in the ELP1 gene; relevant for Ashkenazi Jewish descent
- Familial Hyperinsulinism (ABCC8-Related)3 variants in the ABCC8 gene; relevant for Ashkenazi Jewish descent
- Familial Mediterranean Fever7 variants in the MEFV gene; relevant for Arab, Armenian, Sephardic Jewish, Turkish descent
- Fanconi Anemia Group C3 variants in the FANCC gene; relevant for Ashkenazi Jewish descent
- GRACILE Syndrome1 variant in the BCS1L gene; relevant for Finnish descent
- Gaucher Disease Type 13 variants in the GBA gene; relevant for Ashkenazi Jewish descent
- Glycogen Storage Disease Type Ia1 variant in the G6PC gene; relevant for Ashkenazi Jewish descent
- Glycogen Storage Disease Type Ib2 variants in the SLC37A4 gene
- Hereditary Fructose Intolerance4 variants in the ALDOB gene; relevant for European descent
- Leigh Syndrome, French Canadian Type1 variant in the LRPPRC gene; relevant for French Canadian descent
- Limb-Girdle Muscular Dystrophy Type 2D1 variant in the SGCA gene
- Limb-Girdle Muscular Dystrophy Type 2E1 variant in the SGCB gene; relevant for Amish descent
- Limb-Girdle Muscular Dystrophy Type 2I1 variant in the FKRP gene
- MCAD Deficiency4 variants in the ACADM gene; relevant for European descent
- Maple Syrup Urine Disease Type 1B2 variants in the BCKDHB gene; relevant for Ashkenazi Jewish descent
- Mucolipidosis Type IV1 variant in the MCOLN1 gene; relevant for Ashkenazi Jewish descent
- Neuronal Ceroid Lipofuscinosis (CLN5-Related)1 variant in the CLN5 gene; relevant for Finnish descent
- Neuronal Ceroid Lipofuscinosis (PPT1-Related)3 variants in the PPT1 gene; relevant for Finnish descent
- Niemann-Pick Disease Type A3 variants in the SMPD1 gene; relevant for Ashkenazi Jewish descent
- Nijmegen Breakage Syndrome1 variant in the NBN gene
- Nonsyndromic Hearing Loss and Deafness, DFNB1 (GJB2-Related)8 variants in the GJB2 gene; relevant for many ethnicities, including Ashkenazi Jewish, East/Southeast Asian, European, and Ghanaian descent. May also be relevant for Hispanic/Latino, Northern African/Middle Eastern, and South Asian descent
- Pendred Syndrome and DFNB4 Hearing Loss (SLC26A4-Related)6 variants in the SLC26A4 gene
- Phenylketonuria and Related Disorders23 variants in the PAH gene; relevant for Irish, Northern European descent
- Pompe Disease5 variants in the GAA gene; relevant for African/African American descent; variants also common in European descent
- Primary Hyperoxaluria Type 21 variant in the GRHPR gene
- Pyruvate Kinase Deficiency1 variant in the PKLR gene
- Rhizomelic Chondrodysplasia Punctata Type 11 variant in the PEX7 gene
- Salla Disease1 variant in the SLC17A5 gene; relevant for Finnish, Swedish descent
- Severe Junctional Epidermolysis Bullosa (LAMB3-Related)3 variants in the LAMB3 gene
- Sickle Cell Anemia1 variant in the HBB gene; relevant for African, Middle Eastern, South Asian, Caribbean, Mediterranean, Central and South American descent
- Sjögren-Larsson Syndrome1 variant in the ALDH3A2 gene; relevant for Swedish descent
- Tay-Sachs Disease4 variants in the HEXA gene; relevant for Ashkenazi Jewish, Cajun descent
- Tyrosinemia Type I4 variants in the FAH gene; relevant for French Canadian, Finnish descent
- Usher Syndrome Type 1F1 variant in the PCDH15 gene; relevant for Ashkenazi Jewish descent
- Usher Syndrome Type 3A1 variant in the CLRN1 gene; relevant for Ashkenazi Jewish descent
- Zellweger Spectrum Disorder (PEX1-Related)1 variant in the PEX1 gene
- Cat Allergy
- Dog Allergy
- Nearsightedness
- Seasonal Allergies
- Alcohol Flush Reaction
- Caffeine Consumption
- Deep Sleep
- Genetic Weight
- Lactose Intolerance
- Muscle Composition
- Saturated Fat and Weight
- Sleep Movement
- CYP2C19 Drug Metabolism*DNA variants that influence how the body processes certain medications for depression, acid reflux, heart disease and other conditions3 variants in the CYP2C19 gene; variant found and studied in many ethnicities. Example medications: citalopram, omeprazole, clopidogrel
- Citalopram Medication InsightMedication Insight about how DNA variants may affect citalopram, a medication used to treat depression
- Clopidogrel Medication InsightMedication Insight about how DNA variants may affect clopidogrel, a medication used to reduce the risk for heart attack and stroke
- Citalopram Medication Insight
- DPYD Drug Metabolism*DNA variants that influence how the body processes certain cancer medications2 variants in the DPYD gene; variant found and studied in many ethnicities. Example medications: fluorouracil (5-FU), capecitabine
- SLCO1B1 Drug Transport*A DNA variant that influences how the body processes certain cholesterol-lowering medications1 variant in the SLCO1B1 gene; variant found and studied in many ethnicities
- Simvastatin Medication InsightMedication Insight about how DNA variants may affect simvastatin, a medication used to lower cholesterol levels and reduce the risk for heart attack, stroke, and other heart problems
- Simvastatin Medication Insight
Frequently Asked Questions
To be eligible for 23andMeplus Total Health, you must be 18 years or older and live in the US - excluding HI, NJ, NY, OK, RI and US territories (due to state and regional restrictions). You must not have received a blood transfusion in the last 30 days or a bone marrow transplant.
Currently, Total Health is only available to new, non-genotyped customers. If you're a current customer, we're still in the process of building an upgrade path for you to upgrade within your current account. We want to ensure all the foundations are in place for you to have an optimal experience with the service at a special upgrade price.
Because there are multiple steps involved with 23andMeplus Total Health, your reports will arrive over a period of time after you complete certain steps. The estimated timeline is as follows:
- You'll receive 190+ genotyping reports 4-6 weeks after registering your kit, spitting and shipping your sample.
- You'll receive your exome sequencing reports 7-12 weeks after you receive your genotyping reports.
- For each of the two blood tests, you'll receive your analysis of 55+ biomarkers 3-5 business days after completing your blood draw.
- You'll have unlimited messaging with clinicians after receiving your PGS results and the opportunity to schedule your virtual consultation once exome results are returned.
All saliva samples are processed in Clinical Laboratory Improvement Amendments (CLIA) certified and College of American Pathologists (CAP) accredited labs.
Clinical services are provided by healthcare providers which includes board-certified physicians and nurse practitioners. All clinicians have unique knowledge and training in genetics-informed care.
Genotyping examines DNA variants at certain pre-identified positions in the genome. The specific variants we look at provide coverage of common known variations across the entire genome. Many variants can be accurately and efficiently examined at once using genotyping chips, also known as microarrays. This is the technology used to power the 190+ genotyping reports that you will receive.
Sequencing is an advanced type of genetic testing which involves determining the exact sequence of a certain length of DNA - a short piece, the whole genome, or parts of the genome such as the exome. It can be used to examine known variants, as well as identify variants that are unknown, providing you with a more complete picture of your genetic predispositions for certain health conditions. Exome sequencing looks at approximately40 times more DNA bases than microarray genotyping chips.
Exome sequencing is a specialized genetic sequencing technique that focuses on decoding the exome of an individual's genome. The exome represents the protein-coding regions of genes, which make up only about 1-2% of the entire genome but contain the majority of genetic variants associated with disease risk. By selectively sequencing these regions, exome sequencing provides valuable insights into an individual's genetic makeup, identifying variations that may be linked to specific genetic disorders or conditions. This technique is particularly useful for diagnosing rare genetic diseases and conducting research into the genetic basis of various medical conditions.
The 100+ genes included in the 23andMeplus Total Health Exome Sequencing reports were carefully selected to provide high-impact genetic risk information for 55+ conditions. These include all of the genes considered “medically actionable” by the American College of Medical Genetics and Genomics (ACMG) along with other genes that can provide both clinical and personal benefit. Overall, the genes selected can inform you about conditions that are often underdiagnosed. But, if detected early, there are many effective preventive measures and clinical interventions. See a full list of the genes and conditions .
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*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet FDA requirements for genetic health risks and reports which are based on 23andMe research and have not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child's risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of 44 variants in the BRCA1 and BRCA2 genes. The report describes if a person's genetic result is associated with an increased risk of developing breast cancer and ovarian cancer and may be associated with an increased risk for prostate cancer, pancreatic cancer, and potentially other cancers. The variants included in this report do not represent the majority of the BRCA1/BRCA2 variants in people of most ethnicities. This report does not include variants in other genes linked to hereditary cancers and the absence of variants included in this report does not rule out the presence of other genetic variants that may impact cancer risk. This report is for over-the-counter use by adults over the age of 18, and provides genetic information to inform discussions with a healthcare professional. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed in a clinical setting before taking any medical action. For important information and limitations regarding each genetic health risk and carrier status report, visit 23andme.com/test-info/
**23andMe PGS Pharmacogenetics reports: The 23andMe test uses qualitative genotyping to detect 3 variants in the CYP2C19 gene, 2 variants in the DPYD gene and 1 variant in the SLCO1B1 gene in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic. Our CYP2C19 Pharmacogenetics report provides certain information about variants associated with metabolism of some therapeutics and provides interpretive drug information regarding the potential effect of citalopram and clopidogrel therapy. Our SLCO1B1 Pharmacogenetics report provides certain information about variants associated with the processing of some therapeutics and provides interpretive drug information regarding the potential effect of simvastatin therapy. Our DPYD Pharmacogenetics report does not describe the association between detected variants and any specific therapeutic. Results for DPYD and certain CYP2C19 results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For important information and limitations regarding Pharmacogenetic reports, visit 23andme.com/test-info/pharmacogenetics/
triangleExome Sequencing and blood testing services are available to eligible customers upon completion of the intake questionnaire that must be reviewed, approved and ordered by a third-party clinician. Exome Sequencing is analyzed by a CLIA- and CAP-accredited laboratory. Blood testing is completed by Quest Diagnostics. All telehealth services are provided in accordance with the Telehealth Terms and Consent Telehealth.